Laila Ibrahim

Laila Ibrahim 300px

Royal Children’s Hospital Melbourne

Dr Laila Ibrahim MB BCh BAO, MRCPI, FRACP, PhD is a clinician researcher with a strong research interest in antibiotic use/misuse in children in hospital and at home. She is a Consultant Paediatrician at the Royal Children’s Hospital Melbourne, Clinician Scientist Fellow at the MCRI and Honorary Lecturer at the University of Melbourne and. She is recognised as a specialist paediatrician not only in Ireland where she trained but she has also in Australia. She is focused on treating children out of hospital through her clinical work and as a researcher. As a clinician, Laila was instrumental in transferring patients requiring intravenous antibiotics for acute infections, directly from the Emergency Department to Hospital-In-The-Home, which is both innovative and demonstrates excellence in clinical care. Her research work on children with moderate/severe cellulitis was published in the Lancet Infectious Diseases demonstrated that home intravenous antibiotics was as good as standard care in hospital, preferred by families and more cost-effective. Her post-doctoral program is now focussed on urinary tract infections, through a randomised trial of 1 versus 3 days of intravenous antibiotics for complicated UTI across Australia and New Zealand, which was recently awarded an MRFF funding of $1.6million. This study will provide evidence for the optimal duration of intravenous antibiotics for complicated UTI which has significant impact on antibiotic resistance and quality of life.

Simon Jiang

Dr Simon Jiang from The John Curtin School of Medical Research. Dr Jiang has lead research that has discovered the genetic cause of Lupus.

Staff Specialist Nephrologist, The Canberra Hospital and Research Fellow at the John Curtin School of Medical Research and Centre for Personalised Immunology, ANU

Simon is a staff specialist nephrologist at The Canberra Hospital and Research Fellow at the John Curtin School of Medical Research and Centre for Personalised Immunology, ANU. He completed his PhD as an NHMRC/RACP scholar investigating the role of genetic variation in systemic lupus erythematosus.

His research group focuses on the genetic and molecular basis of autoimmunity and kidney disease, emphasising the mechanisms contributing to organ-specific disease. Simon is project lead investigating the genetics of systemic autoimmunity at the Centre for Personalised Immunology, JCSMR; chief investigator for the Genetic Variation in Immune-Mediated Kidney Disease study, Canberra Hospital; and co-lead investigator researching the genetic and molecular basis of chronic kidney disease endemic amongst Tiwi Islanders. As founding chair of the Translational Glomerulonephritis Clinic at The Canberra Hospital he incorporates genomics and immunophenotyping in personalised treatment of patients with autoimmune kidney disease.

He was recipient of the 2016 NHMRC award for the highest ranking project grant investigating the genetic basis of lupus.

Alison Overeem – Welcome To Country

Alison Overeem is a proud palawa woman from South-East Tasmania who is driven by culture, family, empowerment and creating safe spaces to build hope and dignity.

Alison is passionate about raising awareness of Aboriginal culture and history and the rights of women in society. As a result, Alison has been a member of the Tasmanian Women’s Council since 2015.

While working in aged care at the age of 16, Alison studied for a Bachelor of Education (Early Childhood) and graduated in 1989.

Alison established the Aboriginal Children’s Centre at West Moonah in 1989. As Director of the Aboriginal Children’s Centre from 1989 to 2013, she helped design a state-of-the-art, award-winning, culturally inclusive children’s centre at Risdon Cove. Alison believes she was fortunate to be at the forefront of developing a multifunctional Aboriginal service, the first of its kind in Tasmania. It was, in fact, a precursor to the Child and Family Centres rolled out across Tasmania in recent years.

In 2013, Alison was appointed as the Leprena Centre Manager, Uniting Aboriginal and Islander Christian Congress (UAICC Tasmania). Alison has been instrumental in broadening Leprena’s engagement, networking and connections. On an average week, Leprena engages with about 80 young people.

Leprena offers a variety of activities such as children’s programs, family support programs, training and development, and mentoring. Leprena also acts as a conduit for the wider community seeking to connect with Indigenous people, and frequently engages with non-Aboriginal groups to provide ‘Welcome to Country’ experiences. Alison believes these experiences are vital in helping to close the gap between First and Second Peoples.

Alison has made numerous contributions to publications and resources to promote National Aboriginal and Islander Children’s Day and culturally inclusive practice models of service delivery for Aboriginal communities. Alison’s membership of the National Aboriginal and Islander and Childcare Executive enabled her to provide representations on issues impacting children and families in Tasmania.

Kirsty Morris

Dr Kirsty Morris is a consultation-liaison psychiatrist at Royal Prince Alfred Hospital. She works with the Department of Renal Medicine, seeing inpatients and outpatients at different stages of illness. Dr Morris also consults to other medical teams, surgical teams and the emergency department. She is a member of the Sydney Local Health District Ethics of Clinical Practice Subcommittee.

Getting to the Sofitel

There are a number of airport transportation options available:

  • Limousine or luxury people mover: Brunel Chauffeur Drive will meet Sofitel guests at the airport, pre-booking is required with concierge – please email concierge with the following information:
  • Passenger name: salutation/given name/family name
  • Passenger mobile phone number:
  • Arrival day into Sydney:
  • Arrival date:
  • Arrival time:
  • Flight number:
  • Vehicle type required:

Luxury European Sedan (Audi A8 – maximum three passengers with maximum three medium-sized suitcases, $125.00)

Luxury European SUV (Audi Q7 – maximum three passengers with maximum three large-sized suitcases, $143.00)

Luxury People Mover (Mercedes Viano – maximum six passengers, $178.00)

  • Number of passengers:
    *Please note there is an extra $16.50 for child seat for each vehicle if required.
  • Taxi: Approximately $60-$75 (on meter) plus an airport taxi tax of $3.50 and a tunnel toll of $5.50. Pre-booking is not required, just join the queue at the airport taxi rank. Travel time is 40-45 minutes.
  • Train: Approximately $17 per person to Town Hall followed by a 10 minute downhill walk along Druitt Street to Darling Harbour. A change can be made at Central to the Light Rail. Convention Station is directly across from Sofitel Sydney Darling Harbour.
  • Shuttle Bus: $16-$22 per person, pre-booking is not required – please go to the Redy2Go desk at the airport or just follow the shuttle bus signs to select a different shuttle service. Please note, shuttle buses generally take over an hour to reach the hotel as they travel via various hotels and services usually cease at approximately 8:30pm. Travel times vary but usually over an hour.

Kingsford Smith Airport is located approximately 13 kilometres from the city and the driving time to the Sofitel is around 35-40 minutes.

Should you require any additional information, please feel free to email the Sofitel or call concierge on +61 2 8388 8858.

MITOCHONDRIAL DYSFUNCTION DEFINES A POPULATION OF YOUNG PEOPLE WITH TYPE 1 DIABETES AT RISK OF KIDNEY DISEASE

JM FORBES1,2, NB FLEMMING1,2, DA MCCARTHY1, K BOOT3, N DE SILVA4, LA GALLO1,2, J NISBETT4, A MORTON4, S TEASDALE4, DR THORBURN5, A RUSSELL6, N ISBEL6, D JOHNSON6, G MORAHAN7, T JONES8, J COUPER9, K DONAGHUE10, MP HODSON2,11, T O’MOORE-SULLIVAN4

1Mater Research Institute – The University of Queensland, TRI, Brisbane, Queensland; Schools of 2Biomedical Sciences, Medicine and Pharmacy, The University of Queensland, St Lucia, Qld; 3David Serisier Respiratory Biobank and 4Diabetes and Endocrine Centre, Mater Health Service, Brisbane, Qld; 5Murdoch Children’s Research Institute, Melbourne, Victoria; 6Metro South Health, Brisbane, Qld; 7Harry Perkins Institute of Medical Research, Perth, WA; 8Telethon Kid’s Institute, Perth, WA; 9Women’s and Children’s Hospital, Adelaide, SA; 10Children’s Hospital at Westmead, Sydney, NSW 11Metabolomics Australia, The University of Queensland, St Lucia, Queensland; Australia.

Aim: The objective of this study was to examine the relationships between mitochondrial and renal function in young people with Type 1 diabetes (T1D).

Background: Recent evidence suggests that kidney disease in T1D develops much earlier than previously appreciated. In adolescents with type 1 diabetes (T1D), the highest tertile of urinary albumin-to-creatinine ratio (uACR), predicts renal and cardiovascular disease risk.

Methods: A cross-sectional cohort of young adults with T1D was recruited [n=100; 20.0±2.8 yrs; M:F-54:46, HbA1c-66.1(12.3) mmol/mol; diabetes duration-10.7±5.2 yrs; BMI-24.5(5.3) kg/m2]. Mean uACR tertiles (3 morning urine samples) were used to divide the study population. Lower (uACR ≤0.66 mg/mmol; n=33) and middle (uACR 0.67-1.16; n=33) tertiles were defined as having low-moderate risk and those in the upper tertile (uACR ≥1.17; n=34) as high risk of future DKD. Mitochondrial function in circulating leukocytes and urinary metabolomics were performed.

Results: Participants had hyperfiltration [CKDEPI eGFR, 135.0(13.8) ml/min/m2) and individuals in the upper tertile of uACR had the highest median eGFR (P <0.031 vs low risk tertile; age, gender and diabetes duration adjusted). In a generalized linear model which included HbA1c, BMI, diabetes duration, sex and age, a significant inverse relationship was identified between eGFR-CKDEPI and logACR in the upper tertile, which was not seen in lower risk tertiles (vs middle, P=9.8×10-5; vs lower, P=2×10-16). Mitochondrial function (ATP dependent respiration) in circulating leukocytes, was decreased in individuals in the higher uACR tertile (P=0.008). Multivariate modelling of urinary metabolites identified a signature which separated the upper uACR tertile from the lower risk tertiles.

Conclusions: Young individuals with type 1 diabetes and higher risk of DKD have mitochondrial dysfunction and an inverse relationship between GFR and uACR.

About ANZSN

The ASM is hosted by Australian and New Zealand Society of Nephrology.

The aims of the Society are to promote and support the study of the kidney and urinary tract in health and disease, and to ensure the highest professional standards for the practice of nephrology in Australia and New Zealand.

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