SPLENIC INFARCTS AND PULMONARY RENAL SYNDROME IN A YOUNG PATIENT WITH DOUBLE-POSITIVE ANTI-GBM AND ANCA-ASSOCIATED VASCULITIS: CASE REPORT

A ALHABOBI1, F RAJAH2, N ALOUDAH3, A OSMAN4, E WALEED ELHASSAN5

1National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, 2National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, 3National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, 4National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia, 5National Guard Hospital, Kind Abdulaziz Medical City, Riyadh, Saudi Arabia

Double-positive disease (DPD), defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase ANCA (MPO-ANCA), anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.


Biography:
A Fourth year Internal Medicine resident training in King Abdulaziz Medical City, Riyadh, Saudi Arabia

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