ASSOCIATION BETWEEN DIABETES MELLITUS, WARM ISCHEMIC TIME AND RESISTIVE INDEX, AND EARLY GRAFT FUNCTION AFTER LIVING KIDNEY DONOR TRANSPLANTATION

U SURAPATI1, A NURANI1, D  PARTININGRUM1, A ARWANTO1,  L LESTARININGSIH1, S CHASANI1

1RSUP Dr. Kariadi /medical Faculty Universitas Diponegoro, Semarang, Indonesia

Aim: To determine between the associated factors and early graft function (EGF) after living kidney donor transplantation.
Background: Kidney transplantation (KT) is one of the treatment options for End Stage Renal Disease (ESRD) patients. The development of KT in Indonesia and other developing countries is not too rapid, but various health service centers in Indonesia had pioneered a KT program.
Methods: A retrospective cohort study based on complete documents was done. The samples were 44 respondents (from 2012 to January 2020) and 22 respondents (based on the complete Resistive Index (RI) value recorded since 2018). EGF were defined using urine output (UO), including Immediate Graft Function (IGF) which is defined if UO is  ≥0.5 ml /KgBW/hr 24 hours after KT and Delayed Graft Function (DGF) if UO <0.5 ml /KgBW/hr after KT. Patients without co-morbidity DM, those with WIT ≤40 minutes and RI ≤ 0.7 associated with higher IGF.
Results: The multiple logistic regression analysis using 44 samples showed that DM (OR 27.00; 95%CI: 2.38-306.66; p=0.008); warm Ischemic Time (WIT) (OR 20.25; 95%CI: 2.97-137.31; p=0.002) associate with higher EGF. Using 22 samples, only RI associated with lower EGF (OR 0.11;  95%CI: 0.03-0.41; p= 0.002).
Conclusion: DM, WIT and RI are associated factors of EGF in living-donor KT.
Keywords: DM, warm ischemic time, restrictive index, urine output, early graft function


Biography:
– Nephrologist trainee RSUP Dr. Kariadi / Medical Faculty Universitas Diponegoro
– Head of Internal Medicine Department RSUD Sultan Imanuddin Pangkalan Bun, Central Borneo Indonesia

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