SCRUB TYPHUS ASSOCIATED ACUTE KIDNEY INJURY- A TWO YEAR EXPERIENCE FROM A TERTIARY CARE CENTRE IN SOUTH INDIA

K KEEPPALLIL 1,  E INDHUMATHI1, M JAYAKUMAR 1

1Sri Ramachandra Institute Of Higher Education And Research, Chennai, India

Aim: This study aimed to estimate the incidence of Scrub typhus associated AKI and to evaluate the clinical profile, parameters predicting renal involvement and prognosis in scrub typhus infection.

Background: Patients with kidney failure requiring dialysis are at high risk of cardiovascular morbidity and mortality.

Methods:Retrospective study from November 2018 to October 2020 which included all patients diagnosed with scrub typhus infection. Scrub Typhus infection was diagnosed by ELISA technique and AKI was defined as per KDIGO criteria. Demographic, clinical and laboratory data were compared between the groups and analyzed. Results: Our study included 505 patients with scrub typhus infection among whom females constituted 54.6% (n = 276) and males 45.34% (n = 229). The mean age of the adult population was 46.88 ± 15 years. The incidence of AKI in these patients was 22.7% (n=115). Renal replacement therapy was required in 3.16% (n=16) of the cases. AKI and various risk factors in scrub typhus infection were analyzed which showed significant association of AKI with  leucocytosis, thrombocytopenia, hyperbilirubinemia CNS Involvement. Mortality was 4.15% (n=21).

Results:Our study included 505 patients with scrub typhus infection among whom females constituted 54.6% (n = 276) and males 45.34% (n = 229). The mean age of the adult population was 46.88 ± 15 years. The incidence of AKI in these patients was 22.7% (n=115). Renal replacement therapy was required in 3.16% (n=16) of the cases. AKI and various risk factors in scrub typhus infection were analyzed which showed significant association of AKI with  leucocytosis, thrombocytopenia, hyperbilirubinemia CNS Involvement. Mortality was 4.15% (n=21).

Conclusion: The incidence of AKI associated with scrub typhus in our study was 22.7%. MODS, increased total counts, and hyperbilirubinemia predicted AKI in our adult population. Morbidity and mortality associated with scrub typhus can be reduced by early detection and treatment of AKI.


Biography:

Nephrologist in the making. DM Nephrology Resident in Sri Ramachandra Institute of Higher Education and Research, Chennai. Medical graduate from MOSC Medical College, Kerala, South India moved to Pondicherry in 2014 and joined the Department of General Medicine in Pondicherry institute of Medical Sciences as a resident to pursue my passion in Internal Medicine. My interest in my spare time includes travelling, photography, movies and meeting new people.

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