CARDIOVASCULAR COMORBIDITY AND SURVIVAL IN DIALYSIS PATIENTS: A COHORT STUDY OF THE RURAL POPULATION OF UZBEKISTAN

O SHARAPOV 1

1Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan, 2Republican Specialized Scientific Practical Medical Center of Nephrology and Kidney transplantation, Tashkent, Uzbekistan

Aim: To study the survival rate of Uzbek population of chronic kidney disease(CKD) patients receiving hemodialysis(HD

Background: Patients on hemodialysis die in 50-70% of cases due to cardiovascular diseases(CVD). The mortality rate of dialysis patients from CVD is 10-30 times higher than in the general population. Uzbekistan is a country with a rural population of 17 million

Methods: We observed 61 patients (39 men and 22 women) on hemodialysis for 30 months from April 2018 to September 2020 in the Syrdarya region. The average age was 45.5±14.3 years (M±SD). The patients were divided into 2 groups depending on the presence of CVD: Group A included 34 patients (22 men and 12 women) without CVD. Group B consisted of 27 (17 men and 10 women) patients with CVD.

Results: Our analysis showed that 39.3%(n=24) of all patients survived and continued to receive hemodialysis, 13.1%(n=8) underwent Tx and 47.6% (n=29) patients died. During the first 12 months, 11 patients died (38% of all deaths), in the next 12 months another 8(28%) patients died, and 10(34%) patients died within 6 months of a 3rd year. In group A, 47.1%(n=16) patients survived, 14.7% (n=5) underwent Tx, and 38.2%(n=13) patients died. In group B, 29.6%(n=8) continued to receive HD, 11.1%(n=3) underwent Tx, and 59.3%(n=16) patients died. In the Kaplan-Meier survival analysis, S(t) in group A was 0.568 [95% confidence interval (CI) 0.39-0.75], and in group B it was 0.346 [95% CI 0.15-0.54].

Conclusion: A 30-month prospective analysis of the survival rate shows that more than half of patients die during follow-up [S(t)=0.46]. The analysis shows that dialysis patients without CVD have a 64.2% higher survival rate than patients with CVD.


Biography:

I studied at the Tashkent Medical Academy during 2004-2011. Received a Master’s degree from the Tashkent Medical Academy in 2014. Since 2014 I have been working at the Department of Internal Medicine of the Tashkent Pediatric Medical Institute. Since 2018, I also began to work at the Republican Specialized Scientific Practical Medical Center of Nephrology and Kidney transplantation as a PhD fellow.

Member of the ASN, ISN, ERA-EDTA, Russian Dialysis Society. National Representative of ERA-EDTA Young Nephrologists Platform. Regional representative of the ISN NIS and Russia region. Numerous participant in international conferences as a speaker (+ ANZSN ASM 2020).

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