SITUMORANG D1, Nurani A1, Partiningrum D1, Lestariningsih L1, Arwanto A1, Chasani S1
1Nephrology and Hypertension Division, Department of Internal Medicine, Dr. Kariadi Hospital, Semarang, Indonesia
Background: One of organ complications in systemic lupus erythematosus (SLE) is lupus nephritis. Urinalysis abnormalities, with or without elevated anti-DsDNA, are typical in lupus nephritis at the time of diagnosis. The aim of this research is to find out whether there is correlation between anti-DsDNA and degree of proteinuria in lupus nephritis.
Methods: This is a retrospective study which evaluated kidney biopsy at Dr. Kariadi General Hospital between January 2019 and December 2020. We also collected information on age, gender, urinalysis, and anti-DsDNA levels. We gathered histopathological findings of those whose clinically confirmed as lupus nephritis.
Result: We included data from 56 patients, and only 33 had complete data, consisted of 16 (51.5 %) females. Histopathological features showed that the most frequent histopathological class were 16 (48.5%) class III, followed by 8 (24.2%) class II. Proteinuria 3+ was the most frequent symptom contributing for 12 (36.4%) of samples. There was no correlation between anti-dsDNA levels and the degree of proteinuria (r= <0,005, p=0,15).
Conclusion: There is no correlation between Anti-DsDNA levels and the degree of proteinuria in lupus nephritis.
Keywords: lupus nephritis, histopathology type, clinical features, proteinuria
Born: Jakarta, November 19th 1986
Faculty of Medicine, Universitas Kristen Indonesia, General Physician – 2011
Faculty Of Medicine, Universitas Sumatera Utara, Internist- 2019
Faculty of Medicine, Universitas Diponegoro, Nephrology and Hypertension Trainee Program
Dr. Kariadi Hospital, Semarang, Indonesia
Internal Medicine Departement, Universitas Kristen Indonesia Hospital
Indonesian Medical Association
Indonesian Society of Internal Medicine
Indonesia Society of Nephrology
Indonesian Society of Ultrasound in Medicine
International Society of Nephrology