Dr Elisa Bongetti1,2, Associate Professor RAJESH RAJ3,4
1Monash Health, Clayton, Australia, 2Monash University, Clayton, Australia, 3Launceston General Hospital, Launceston, Australia, 4University of Tasmania, Hobart, Australia
Background: Australia has among the highest global incidence rates of biopsy-proven focal and segmental glomerulosclerosis (FSGS). First Nations Australians are particularly vulnerable to end-stage kidney disease (ESKD), yet large-scale studies assessing FSGS are lacking.
Aim: To examine disease incidence and transplantation rate in Indigenous and non-Indigenous Australians with FSGS on renal replacement therapy (RRT) using data from the Australian and New Zealand Dialysis and Transplant Association (ANZDATA) data registry.
Methods: Data was obtained from Australian patients enrolled in the ANZDATA registry with FSGS from January 2000-December 2019. Outcomes were assessed with Chi-squared and two-tailed student t-tests with 95-percent confidence intervals. P values less than 0.05 were deemed statistically significant.
Results: 1691 of 47,149 (3.4%) patients had FSGS during the study period. Of these, 88 patients (5.2%) were Indigenous Australians. The incidence of FSGS was higher in Indigenous than non-Indigenous Australians (1.1 vs 0.5/100,000/year, respectively). Indigenous Australians were 9.5 years younger at RRT initiation (95%CI 6.2-12.9, p<0.001), yet were almost three decades older than non-Indigenous people at time of transplant (57.0 ± 37.8years vs 29.0 ± 27.4years, p<0.001). Zero Indigenous and 78 non-Indigenous patients received pre-emptive renal transplants during the study period. Median survival time for patients with ESKD due to FSGS was 7 years (IQR:3.9-10.6 years) and this did not vary by ethnicity based on the data available.
Conclusions: Indigenous Australians experience a higher incidence of FSGS compared to non-Indigenous Australians, reach ESKD at a younger age and are less likely to receive renal transplantation. Improved access to transplantation and ongoing access to renal health services are required to Indigenous communities.
Biography:
Bio to come