DIAGNOSTIC VALUE OF PODOCIN FOR EARLY DIAGNOSIS OF DIABETIC KIDNEY DISEASES: A META-ANALYSIS
Kiagus Muhammad Yusuf Arief Akbar1,2,3, Novadian Suhaimi1,2,3, Zulkhair Ali1,2,3, Ian Effendi1,2,3, Suprapti Slamet1,2,3, Fadhyl Zuhry Lubis2,3, Eddy Yuristo2,3, Syahpri Putra Wangsa1,2,3, Deddy Primadona Mulia1,2,3, Herleni Kartika1,2,3, Elfiani Elfiani1,2,3, Novandra Abdillah1,2,3, Chairil Makky1,2,3, Rery TF Dr1,2,3, Edy Nur Rachman1,2,3, Ari Dwi Prasetyo2,3, Fauzan Azhari2,31Department of Nephrology and Hypertension, Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia2Department of Internal Medicine, Palembang, South Sumatera, Indonesia3Faculty of Medicine, Sriwijaya University, Palembang, South Sumatera, Indonesia
Abstract
Aim: To assess the diagnostic value of podocin in patients with Diabetic Kidney Disease (DKD).
Background: The most challenging aspects in the treatment of Diabetic Kidney Diseases (DKD) for clinician are early identification and disease monitoring. New biomarkers are being developed in order to improve the diagnostic performance and podocin show potential role for early detection of DKD. However, the overall diagnostic value remains unclear.
Methods: A literature search was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines on PubMed, Cochrane, and Google scholar databases. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and corresponding 95% credible interval (95% CI) were calculated using a bivariate regression model in STATA 16.0 software.
Results: Four studies with a total of 339 patients were included in the analysis. The summary estimates using podocin for detecting patients with DKD were as follows: sensitivity 93% (95% CI: 79%-98%), specificity 96% (95% CI: 88%-99%). Furthermore, the pooled DOR, PLR, NLR of podocin were 348 (95% CI: 41–2959), 26.3 (95% CI: 6.9-100.2), 0.08 (95% CI: 0.02-0.24), respectively. In addition, AUC of KIM-1 were 0.99 (95% CI: 0.97–0.99).
Conclusion: In summary, podocin exerted satisfactory diagnostic performance in early diagnosis of DKD. More study with prospective design with larger population need to validate this result.
Keywords: Podocin, biomarker, diagnosis, Diabetic Kidney Diseases
Biography
I am a Young Trainee Nephrologist (33 years old) of Department Nephrology and Hypertension and Department of Internal Medicine, Mohammad Hoesin General Hospital, Faculty of Medicine, Sriwijaya University, Palembang, South Sumatra, Indonesia